Structure of the feline c-fes/fps proto-oncogene: genesis of a retroviral oncogene
نویسندگان
چکیده
منابع مشابه
RET proto-oncogene mutations in the diagnosis of medullary thyroid cancer: a review article
Medullary thyroid cancer accounts for 5-10% of thyroid carcinomas. RET proto-oncogene mutations occur in all of the hereditary MTCs and about 66% of the sporadic MTCs. So, the detection of the RET mutations is necessary for rapid and proper diagnosis and treatment. This systematic review seeks to find a comprehensive list of RET gene mutations in the diagnosis of medullary thyroid cancer. The ...
متن کاملRET Proto-Oncogene
Hereditary medullary thyroid carcinoma (MTC) is caused by autosomal dominant gain-of-function mutations in the RET proto-oncogene. Associations between specific RET mutations (genotype) and the aggressiveness of MTC and presence or absence of other endocrine neoplasms (phenotype) are well documented. Mutations in six exons (10, 11, 13, 14, 15, and 16) located in either cysteine-rich or tyrosine...
متن کاملReassessment of the murine c-fms proto-oncogene sequence.
The c-fms gene encodes the receptor for the macrophage-colony stimulating factor (M-CSF) which promotes the proliferation and survival of cells of the monocytic lineage (1). A cDNA library was constructed from a murine myeloblastic leukemic cell line, BMC-4, in which the c-fms gene was overexpressed (2). Eleven independent full-length cDNAs were isolated after screening with a probe encompassin...
متن کاملExpression of the c-ret proto-oncogene during mouse embryogenesis.
The c-ret proto-oncogene encodes a receptor tyrosine kinase whose normal function has yet to be determined. To begin to investigate the potential role of this gene in vertebrate development, we have isolated cDNA clones representing the murine c-ret gene, and have analyzed the pattern of expression during mouse embryogenesis, using northern blotting, in situ hybridization to histological sectio...
متن کاملIsolation of the proto-oncogene c-myb from D. melanogaster.
We have isolated the proto-oncogene c-myb from Drosophila melanogaster. This gene is represented by a single locus at position 13E-F on the X chromosome, and is expressed in early embryos by transcription into two polyadenylated RNAs with lengths of approximately 3.0 and 3.8 kb. The gene may encode a protein with a molecular weight of at least 55,000 that shares a domain with c-myb (chicken) in...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1987
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.61.6.2009-2016.1987